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Kaiser

Mixed Ancestry

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@fluffy_kaiserroll

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Genetic Breed Result

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Pembroke Welsh Corgi

The Pembroke Welsh Corgi is a small, energetic, herding dog that is good with families.

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Miniature/MAS-type Australian Shepherd

Miniature American Shepherds (also known as Miniature Australian Shepherds, or Mini Aussies) have the trainability, intelligence and energy of the larger Aussie cousins, and excel at outdoors activities and agility competitions.

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Dogs Like Kaiser

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Discover dogs who share a similar breed mix to Kaiser. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
Pembroke Welsh Corgi
Miniature/MAS-type Australian Shepherd

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Health Summary

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Kaiser is at increased risk for two genetic health conditions.

And inherited one variant that you should learn more about.

Multiple Drug Sensitivity

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Kaiser inherited one copy of the variant we tested

How to interpret this result

Kaiser has one copy of a variant at the ABCB1 gene and is at risk for displaying adverse drug reactions. While he may not be as severely affected as a dog with two copies of the ABCB1 drug sensitivity allele, normal dosages of drugs could still have potentially severe effects on Kaiser. Please inform your veterinarian that Kaiser carries this variant; it is essential that they know this information before prescribing drugs.

What is Multiple Drug Sensitivity?

Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with a mutation in the ABCB1 gene.

Intervertebral Disc Disease (Type I)

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Kaiser inherited one copy of the variant we tested

How to interpret this result

Kaiser has one copy of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

ALT Activity

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Kaiser inherited one copy of the variant we tested

Why is this important to your vet?

Kaiser has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Kaiser has this genotype, as ALT is often used as an indicator of liver health and Kaiser is likely to have a lower than average resting ALT activity. As such, an increase in Kaiser’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD

Identified in Pembroke Welsh Corgis

X-linked Severe Combined Immunodeficiency, X-SCID

Identified in Pembroke Welsh Corgis

Progressive Retinal Atrophy, rcd3

Identified in Pembroke Welsh Corgis

Progressive Retinal Atrophy, prcd

Identified in Miniature/MAS-type Australian Shepherds

Collie Eye Anomaly

Identified in Miniature/MAS-type Australian Shepherds

Canine Multifocal Retinopathy, cmr1

Identified in Miniature/MAS-type Australian Shepherds

Urate Kidney & Bladder Stones

Identified in Miniature/MAS-type Australian Shepherds

Neuronal Ceroid Lipofuscinosis 6, NCL 6

Identified in Miniature/MAS-type Australian Shepherds

Neuronal Ceroid Lipofuscinosis 8, NCL 8

Identified in Miniature/MAS-type Australian Shepherds

Degenerative Myelopathy, DM

Identified in Pembroke Welsh Corgis

Exercise-Induced Collapse, EIC

Identified in Pembroke Welsh Corgis

Craniomandibular Osteopathy, CMO

Identified in Miniature/MAS-type Australian Shepherds

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

Coat Color Modifiers

Other Coat Traits

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Other Body Features

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Through Kaiser’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

C2

Haplotype

C21

Map

C2

Kaiser’s Haplogroup

C2 is a very old female lineage found more commonly among English Setters, English Bulldogs, and American Eskimo Dogs. We also see C2 in village dogs in South Asia. Rather than having a few characteristic breeds representing this lineage particularly well, it is present in a few uncommon individuals of many different breeds. Unlike some European breed lineages that have seen skyrocketing popularity along the path to the modern dogs we see today, C2 tends to reflect the deep history of man's best friend.

C21

Kaiser’s Haplotype

Part of the C2 haplogroup, this haplotype occurs most commonly in Border Collies, Australian Cattle Dogs, and village dogs in Fiji.

You can often find his haplogroup in the lovable English Bulldog.

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Through Kaiser’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.14

Map

A1a

Kaiser’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.14

Kaiser’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs mainly in village dogs from Central and South Americas, but has also been spotted in Papua New Guinea. It also occurs frequently in Cocker Spaniels, English Cocker Spaniels, and Pembroke Welsh Corgis.

Dogs with A1a lineage travelled during European Colonial times.

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