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River

Mixed Ancestry

“She was picked up as a stray in North Carolina and we adopted her in northern Virginia. She is very energetic and loves to play. She's also very affectionate after she gets to know people and loves to please. This makes training with treats very easy and a blast for her. Although not AKC, we think she may be a mountain cur. Her records indicated multiple things that didn't quite fit such as plott hound and terrier.”

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Genetic Breed Result

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Mountain Cur

Mountain Curs are an American breed of treeing hound. Developed in the South—particularly Kentucky, Virginia, and Tennessee—Mountain Curs are an all-American breed that has been prized for years as excellent hunting companions and loyal pets.

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Staffordshire Terrier

Staffordshire Terriers, sometimes referred to as "pit bull" type, are intelligent and trainable dogs. They can have a lot of energy and are often great canine athletes!

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Beagle

The Beagle is a scent hound and a great family pet. They are known for being affectionate and having loud voices.

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Labrador Retriever

The Labrador Retriever was bred for hunting and excelled in retrieving game after it was shot down. Known for its gentle disposition and loyalty, the Labrador Retriever has become a favorite of families and breeders alike.

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Dogs Like River

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Discover dogs who share a similar breed mix to River. A higher score means the two dogs have more of their breed mix in common. A score of 100% means they share the exact same breed mix!

Click or tap on a pic to learn more about each dog and see an in-depth comparison of their DNA, breeds, and more.

DNA Breed Origins

Breed colors:
Mountain Cur
Staffordshire Terrier
Beagle
Labrador Retriever

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Here’s what River’s family tree may have looked like.
While there may be other possible configurations of her family’s relationships, this is the most likely family tree to explain River’s breed mix.
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Health Summary

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River is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Intervertebral Disc Disease (Type I)

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River inherited one copy of the variant we tested

How to interpret this result

River has one copy of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

Degenerative Myelopathy, DM

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River inherited one copy of the variant we tested

What does this result mean?

This variant should not impact River’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. River is unlikely to develop this condition due to this variant because she only has one copy of the variant.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

Breed-Relevant Genetic Conditions

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Factor VII Deficiency

Identified in Beagles

Canine Elliptocytosis

Identified in Labrador Retrievers

Pyruvate Kinase Deficiency

Identified in Labrador Retrievers

Pyruvate Kinase Deficiency

Identified in Beagles

Progressive Retinal Atrophy, prcd

Identified in Labrador Retrievers

Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2

Identified in Labrador Retrievers

Progressive Retinal Atrophy, crd1

Identified in Staffordshire Terriers

Progressive Retinal Atrophy, crd2

Identified in Staffordshire Terriers

Progressive Retinal Atrophy, crd4/cord1

Identified in Beagles and Labrador Retrievers

Day Blindness

Identified in Labrador Retrievers

Primary Open Angle Glaucoma

Identified in Beagles

Hereditary Cataracts

Identified in Staffordshire Terriers

Macular Corneal Dystrophy, MCD

Identified in Labrador Retrievers

Urate Kidney & Bladder Stones

Identified in Labrador Retrievers and Staffordshire Terriers

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A

Identified in Staffordshire Terriers

Alexander Disease

Identified in Labrador Retrievers

Neonatal Cerebellar Cortical Degeneration

Identified in Beagles

L-2-Hydroxyglutaricaciduria, L2HGA

Identified in Staffordshire Terriers

Narcolepsy

Identified in Labrador Retrievers

Centronuclear Myopathy, CNM

Identified in Labrador Retrievers

Exercise-Induced Collapse, EIC

Identified in Labrador Retrievers

X-Linked Myotubular Myopathy

Identified in Labrador Retrievers

Hypocatalasia, Acatalasemia

Identified in Beagles

Cobalamin Malabsorption

Identified in Beagles

Congenital Myasthenic Syndrome, CMS

Identified in Labrador Retrievers

Hereditary Nasal Parakeratosis, HNPK

Identified in Labrador Retrievers

Musladin-Lueke Syndrome, MLS

Identified in Beagles

Osteogenesis Imperfecta

Identified in Beagles

Skeletal Dysplasia 2, SD2

Identified in Labrador Retrievers

Additional Genetic Conditions

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Through River’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A17

Map

A1a

River’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A17

River’s Haplotype

Part of the large A1a haplogroup, this common haplotype is found in village dogs across the globe. Among breed dogs, we find it most frequently in Labrador Retrievers, Boxers, and Mastiffs.

Shar Pei dogs think A1a is the coolest!

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that River inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since River is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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