Talcon inherited one copy of the variant we tested
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“Talcon is a Shalom Shepherd from Native Sky Kennel and I was told that he is 75% Native American Indian Dog and 25% German Shepherd. There is dispute about the actual origins of the NAID so I am hoping to get some answers about his genetic make up. His parents were not health tested so I am more interested in finding out if he is a carrier for certain genetic diseases.”
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Health Summary
Talcon inherited one variant that you should learn more about.
Degenerative Myelopathy, DM
What does this result mean?
This variant should not impact Talcon’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Talcon is unlikely to develop this condition due to this variant because he only has one copy of the variant.
Impact on Breeding
Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.
What is Degenerative Myelopathy, DM?
The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.
Breed-Relevant Genetic Conditions
Multiple Drug Sensitivity (ABCB1)
Identified in German Shepherd Dogs
Variant not detected
Factor VII Deficiency (F7 Exon 5)
Identified in Alaskan Malamutes
Variant not detected
Hemophilia A (F8 Exon 11, German Shepherd Variant 1)
Identified in German Shepherd Dogs
Variant not detected
Hemophilia A (F8 Exon 1, German Shepherd Variant 2)
Identified in German Shepherd Dogs
Variant not detected
Canine Leukocyte Adhesion Deficiency Type III, CLAD III (FERMT3, German Shepherd Variant)
Identified in German Shepherd Dogs
Variant not detected
Day Blindness (CNGA3 Exon 7, German Shepherd Variant)
Identified in German Shepherd Dogs
Variant not detected
Urate Kidney & Bladder Stones (SLC2A9)
Identified in German Shepherd Dogs
Variant not detected
Anhidrotic Ectodermal Dysplasia (EDA Intron 8)
Identified in German Shepherd Dogs
Variant not detected
Renal Cystadenocarcinoma and Nodular Dermatofibrosis (FLCN Exon 7)
Identified in German Shepherd Dogs
Variant not detected
Mucopolysaccharidosis Type VII, Sly Syndrome, MPS VII (GUSB Exon 3, German Shepherd Variant)
Identified in German Shepherd Dogs
Variant not detected
GM1 Gangliosidosis (GLB1 Exon 15, Alaskan Husky Variant)
Identified in Siberian Huskies
Variant not detected
Alaskan Malamute Polyneuropathy, AMPN (NDRG1 SNP)
Identified in Alaskan Malamutes
Variant not detected
Additional Genetic Conditions
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What is a linkage test?
DNA sequences that are close together on a chromosome tend to be inherited together. Because of this, we can use genetic variation surrounding a specific variant (i.e. "linked" to it) to infer the presence or absence of a variant that is associated with a health condition or trait.
Linkage tests are not as predictive of your dog’s true genotype as direct assays, which we use on most other genetic conditions we test for.
Traits
Explore the genetics behind your dog’s appearance and size.
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Coat Color
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Coat Traits
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Other Body Features
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.
Body Size
No Result
For every test, we run multiple assays to ensure the accuracy of the results we deliver. For your dog, one or more of these produced inconclusive or low confident results. Therefore, we are not able to provide you with a result at this time.