Cleft Lip and/or Cleft Palate

Skeletal

Cleft lip with and without cleft palate is a condition of embryonic development. Animals are bilateral animals: we have two eyes, two ears, etc. that center around a midline. The mouth, though there is just one, is symmetrical and is formed by two planes of tissues that grow towards and fuse at our mildline. Cleft palate occurs when the fusion of the roof of the mouth is incomplete; cleft lip occurs when just the fusion of the upper lip is incomplete.

  • Signs and symptoms

    Puppies that have cleft palate can have difficulty eating and may present for weight loss. They are also more likely to accidentally aspirate food and are often noted to have persistent coughing and a runny nose due to respiratory infections; in severe cases this can progress to pneumonia.

    Signs are first recognized in puppies.

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  • Diagnosis

    Genetic testing and clinical signs can be used to diagnose this condition.

  • Treatment

    Cleft lip without cleft palate is a relatively cosmetic condition that can be corrected surgically if desired. Cleft palate can often be surgically repaired.

  • What to do if your dog is at risk

    Actions

    • Seek your veterinarian's opinion with regard to if a surgical correction should be pursued.

  • Genetic Information

    This mutation was first described in the Nova Scotia Duck Tolling Retriever.

    This mutation has an autosomal recessive inheritance, meaning that dogs must have two copies of the mutation in order to show clinical signs. Many causes of cleft lip and cleft palate do not have a known genetic cause at this time.

    Gene names:

    ADAMTS20 ‐ chr27

    Inheritance type:

    recessive

  • Breeds affected

    This health condition affects the following breeds

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