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This is a hormone condition.

Congenital Hypothyroidism with Goiter

What is Congenital Hypothyroidism with Goiter?

Congenital Hypothyroidism is due to abnormal development of the thyroid gland or improper thyroid hormone synthesis. This is a medically manageable condition. This variant in the thyroid peroxidase (TPO) gene causes a failure of the biochemical process with iodide in the thyroid gland and the presence of a goiter.

What are the signs & symptoms that develop in affected dogs?

Affected dogs may have mental dullness, disproportionate dwarfism, abnormal haircoat and skin, a large protruding tongue, and a lump on their throat region (goiter).

When do signs and symptoms develop?

Signs first develop in puppyhood and continue throughout their lives if untreated.

How do vets diagnose this condition?

Genetic and laboratory testing, along with clinical signs, are used to diagnose this disease.

How is this condition treated?

Other forms of Congenital Hypothyroidism with Goiter (CHG) can be lethal if not diagnosed and treated in a timely manner. The reported case of CHG due to this TPO variant had more mild symptoms than those due to previously reported variants. Affected dogs can be treated with lifelong hormone replacement.

What actions should I take if my dog is affected?

  • Early diagnosis, consistent treatment, and regular blood work are key to managing this condition well.
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