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Metabolic

This is a Metabolic condition.

Succinic Semialdehyde Dehydrogenase Deficiency

What is SSADH Deficiency?

A seizure disorder reported in Salukis has been determined to be due to a variant in the ALDH5A1 gene which causes Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency. In addition to seizures, affected puppies can display abnormal behavior such as episodes of vocalization and difficulty being roused from sleep.

What are the signs & symptoms that develop in affected dogs?

Affected dogs may have a history of seizures and behavioral changes, such as vocalization episodes and difficulty being roused from sleep. Puppies may appear uncoordinated or have a delayed ability to properly position their paws.

When do signs and symptoms develop?

Clinical signs may be observed between 6 and 10 weeks of age.

How do vets diagnose this condition?

Genetic testing, clinical signs, history, and ruling out other causes of similar symptoms can be used in conjunction to diagnose this disease. Your veterinarian may recommend magnetic resonance imaging (MRI) of the brain and cerebrospinal fluid (CSF) analysis.

How is this condition treated?

Frank discussions about quality of life are warranted. Although clinical signs may not progress, many owners request that puppies be euthanized between 3 and 9 months of age for quality of life concerns (e.g. recurrent episodes of vocalization).

What actions should I take if my dog is affected?

  • There are no effective treatments specifically for SSADH deficiency.
  • Anticonvulsant therapy may help control seizures, but is not a cure for SSADH Deficiency.
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