Lethal Acrodermatitis, LAD
Lethal Acrodermatitis is a severe condition characterized by ulcerated skin lesions on the paws and head and a coat color dilution. The immunodeficiency common with this condition also causes intestinal upset, bronchopneumonia, and a general failure to thrive.
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Signs and symptoms
Signs include red and ulcerated patches on the head and paws and coat color dilution. The skin lesions progress to the legs and muzzle. Respiratory signs, diarrhea, and poor growth are also common.
Signs are often first recognized in puppies as young as 3-4 weeks of age. -
Diagnosis
Genetic testing and clinical signs can be used to diagnose this condition.
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Treatment
Unfortunately, there is no treatment for this condition. Certain medications can help control the infections for a period of time, but most puppies are euthanized early in life.
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What to do if your dog is at risk
Actions
- Follow your veterinarian's recommendations and give any medications as prescribed.
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Genetic Information
This mutation was first described in the Bull Terrier and Miniature Bull Terrier.
This mutation has an autosomal recessive inheritance, meaning that dogs must have two copies of the mutation in order to show clinical signs.
Gene names:
MKLN1 ‐ chr14
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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