This is a Clinical condition.
Multiple Drug Sensitivity
What is MDR1?
Sensitivity to certain classes of drugs, notably the parasiticide ivermectin, as well as certain gastroprotectant and anti-cancer medications, occurs in dogs with a mutation in the ABCB1 gene.
What are the signs & symptoms that develop in affected dogs?
MDR1 often presents in young adulthood, only because this is most commonly when a dog is first exposed to a problem drug like high dose ivermectin or acepromazine.
When do signs and symptoms develop?
Symptoms arise after a dog has received an MDR1 problem drug or dosage, and can range from vomiting and diarrhea to lethargy, seizures, or coma.
How do vets diagnose this condition?
This is usually a retroactive diagnosis after a dog has an adverse reaction to a problem drug--however, genetic testing could help you avoid a first reaction altogether.
How is this condition treated?
MDR1 is perfectly avoidable simply by avoiding the problem drugs, or problem dosages.
What actions should I take if my dog is affected?
- Review the MDR1 Problem Drug List as described by Washington State University and notify your veterinarian to flag this in your dog’s file!
- Farm dogs with MDR1 may also benefit if they are either kept away from herds where ivermectin is used as a routine antiparasitic, or if another form of antiparasitic is used in areas that they are working.
