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This is a Blood condition.

P2Y12 Receptor Platelet Disorder

What is P2Y12 Receptor Platelet Disorder?

P2Y12 deficiency is a coagulopathy, or disorder of blood clotting, which affects platelet function. This mutation does not cause spontaneous bleeding but will cause excessive bleeding following a trauma or surgery.

What are the signs & symptoms that develop in affected dogs?

Affected puppies may bleed abnormally when teething. You may notice extensive bruising or bleeding that does not stop following a traumatic event.

When do signs and symptoms develop?

Signs may occur at any age but are most often recognized in young dogs during an elective surgery or following a trauma.

How do vets diagnose this condition?

Genetic or laboratory testing is necessary to diagnose P2Y12 deficiency. If you have a Greater Swiss Mountain Dog, you should absolutely test them for this disorder prior to surgery.

How is this condition treated?

Currently there is no treatment for this disorder. If your dog must have surgery, your veterinarian should be prepared to provide multiple transfusions during and/or after the procedure.

What actions should I take if my dog is affected?

  • Prevention is key! Minimizing the risk of trauma and informing your veterinarian so that surgeries can be carefully planned are the best ways to prevent a catastrophic outcome.
  • Be aware of the location of the nearest emergency veterinary hospital in case of an accident.
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