Primary Ciliary Dyskinesia, PCD

Multisystem

PCD arises from a mutation that inhibits the function of motile cellular appendages such as sperm flagella and the cilia of respiratory tract cells. These appendages whip with directionality, allowing sperm to propel themselves towards an egg, and for respiratory tract cells to whip dust, bacteria, and mucus up towards the throat to be coughed out.

  • Signs and symptoms

    This disease can cause increased susceptibility to respiratory infections and, in male dogs, reduced fertility or infertility.

    Respiratory infections can develop at anytime, however, male fertility can only be assessed after puberty.

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  • Diagnosis

    Genetic and laboratory testing are used to diagnose this condition.

  • Treatment

    There is no cure for PCD. Respiratory infections need to be treated promptly with the correct antibiotic.

  • What to do if your dog is at risk

    Actions

    • Carefully monitor your dog for signs of infection, including: coughing, nasal discharge, and increased respiratory effort.

  • Genetic Information

    This mutation was first described in the Alaskan Malamute.

    This mutation is inherited in an autosomal recessive manner; that is, a dog requires two copies of the mutation to show signs of the disease.

    Gene names:

    NME5 ‐ chr11

    Inheritance type:

    recessive

  • Breeds affected

    This health condition affects the following breeds

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