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Clinical

This is a Clinical condition.

ACE Activity

What is ACE Activity?

Heart disease in dogs is often managed with a class of drugs known as ACE-I (angiotensin-converting enzyme inhibitors). This gene mutation causes a decrease in the activity of ACE (angiotensin-converting enzyme). ACE acts in the body as a fluid regulator and causes blood vessels to constrict. This increases blood pressure. This mutation was originally described in the Cavalier King Charles Spaniel. Two copies of this mutation cause a natural drop in baseline ACE activity. Dogs are born with this clinical trait. You should not notice any signs of this condition in your dog. Genetic testing is the only way to know if your dog has this gene mutation. Dogs with heart disease and this mutation should still be prescribed ACE inhibitors if recommended by your veterinarian. ACE inhibitors were found to reduce the activity of ACE regardless of the dog’s genotype for this mutation. Further studies are needed to determine how this mutation impacts the treatment of heart disease in the dog. No actions can be taken at home to change this clinical trait.

What are the signs & symptoms that develop in affected dogs?

You should not notice any signs of this condition in your dog.

When do signs and symptoms develop?

Dogs are born with this clinical trait.

How do vets diagnose this condition?

Genetic testing is the only way to know if your dog has this mutation.

How is this condition treated?

Dogs with heart disease and this mutation should still be prescribed ACE inhibitors if recommended by your veterinarian. ACE inhibitors were found to reduce the activity of ACE regardless of the dog’s genotype for this mutation. Further studies are needed to determine how this mutation impacts the treatment of heart disease in the dog.

What actions should I take if my dog is affected?

No actions can be taken at home to change this clinical trait.

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