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Hematologic

This is a Blood condition.

Canine Leukocyte Adhesion Deficiency Type III, CLAD3

What is CLAD3?

A rare disorder of white blood cells, this causes increased susceptibility to infections and bleeding tendencies. Affected dogs present with a history of persistent skin and gum infections as well as uncontrollable bleeding from small cuts. Dogs with CLAD Type III can live many years as long as serious infections are treated with antibiotic therapy. It is also crucial that veterinarians performing surgery on CLAD Type III dogs have blood on hand for transfusion.

What are the signs & symptoms that develop in affected dogs?

Affected dogs may have recurrent, severe skin infections (pyoderma), limping (lameness), and/or swollen, bleeding gums (gingivitis).

When do signs and symptoms develop?

This disease is typically diagnosed in puppies or young adults when they experience chronic infections and/or bleeding following a spay or neuter.

How do vets diagnose this condition?

Genetic or laboratory tests are performed to diagnose this condition.

How is this condition treated?

Currently, treatment for CLAD3 focuses on symptomatic management. Judicious, chronic antibiotic use is typically required. Blood products will need to be given following a trauma or surgery.

What actions should I take if my dog is affected?

Prevention is ideal, but affected dogs often have a shortened life span despite their owners’ best efforts. Regular bathing with antiseptic shampoos, routine dental care, minimizing the risk of trauma and informing your veterinarian so that surgeries can be carefully planned are the best ways to prevent a poor outcome. Be aware of the location of the nearest emergency veterinary hospital.

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