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Muscular

This is a Muscular condition.

Exercise-Induced Collapse

What is EIC?

First characterized in field-trial lines of Labrador Retriever dogs, this muscle disorder can cause episodes of muscle weakness and sometimes collapse; after recovering, most dogs are perfectly normal and eager to get back to work. While most dogs appear dazed or confused after an episode, most return to normal quickly. Dogs are otherwise normal and healthy, though some severely affected dogs have died during an episode. The factors determining the severity of an episode on a given day or in a given dog is unknown. EIC has been linked to a mutation in the DNM1 gene, which codes for the protein dynamin. In the neuron, dynamin trucks neurotransmitter-filled vesicles from the cell body, where they are generated, to the dendrites. It is hypothesized in dogs affected with EIC, the mutation in DNM1 disrupts efficient neurotransmitter release, leading to a cessation in signalling and EIC.

What are the signs & symptoms that develop in affected dogs?

This muscle disorder can cause episodes of muscle weakness and sometimes collapse. After recovering, most dogs are perfectly normal and eager to get back to work. While most dogs appear dazed or confused after an episode, most return to normal quickly.

When do signs and symptoms develop?

Signs develop in juvenile dogs, typically before 3 years of age.

How do vets diagnose this condition?

Genetic testing, clinical signs, and muscle biopsy can be used to diagnose this disorder.

How is this condition treated?

Dogs with this condition are otherwise normal and healthy, though some severely affected dogs have died during an episode. The factors determining the severity of an episode on a given day or in a given dog is unknown.

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