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Integument

This is a Skin & Connective Tissues condition.

Musladin-Lueke Syndrome

What is MLS?

First characterized in the Beagle, this condition causes abnormally strong connections between the structural proteins that provide strength and integrity to tissues like the skin and skeletal muscle, as well as the protective tissue sheaths of the bones and central nervous system. The easiest things to see, of course, is what’s on the outside: Dogs with MLS typically come to the vet because of severely contracted joints that cause them to walk on their toes, rather than their paw pads. However, due to the effect of the mutation on internal connective tissues, some dogs can also experience seizures. Affected dogs can display a spectrum of disease severities ranging from very mild to severe. While MLS has no cure, all but most severe cases can be managed with supportive care.

What are the signs & symptoms that develop in affected dogs?

Dogs with MLS typically come to the vet because of severely contracted joints that cause them to walk on their toes, rather than their paw pads. However, due to the effect of the mutation on internal connective tissues, some dogs can also experience seizures.

When do signs and symptoms develop?

Signs are often first recognized in puppies.

How do vets diagnose this condition?

Clinical signs, genetic testing, and biopsy can be used to diagnose this condition.

How is this condition treated?

Unfortunately, there is no treatment for MLS. However, all but most severe cases can be managed with supportive care.

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