Multisystem

This is a Multisystem condition.

Anhidrotic Ectodermal Dysplasia

What is XHED or X-LED?

This developmental condition can cause a scanty haircoat, malformed teeth, and few or absent sweat glands. Because dogs only have sweat glands on their paw pads, they are not prone to overheating--other than dietary changes to accomodate missing teeth and appropriate measures to protect skin from sunburn or overdrying, affected dogs can lead healthy and normal lives. In the German Shepherd Dog, XHED has been mapped to a mutation in the EDA gene, leading to a defective ectodysplasin protein, which is known to play a role in hair follicle and tooth bud development.

What are the signs & symptoms that develop in affected dogs?

Affected puppies have symmetrical hair loss and missing or malformed teeth.

When do signs and symptoms develop?

Affected dogs are often first noted at birth, although signs continue to develop into adulthood.

How do vets diagnose this condition?

Genetic and laboratory testing are used to diagnosis this disorder.

How is this condition treated?

Because dogs only have sweat glands on their paw pads, they are not prone to overheating--other than dietary changes to accommodate missing teeth and appropriate measures to protect skin from sunburn or over drying, affected dogs can lead healthy and normal lives.

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