2,8-Dihydroxyadenine Urolithiasis, 2,8-DHA Urolithiasis

If caught early, it can be medically managed. However, 2,8-DHA urolithiasis is hard to diagnose early because the only sign is dark tinged urine. If the stones are allowed to get larger, your dog may have difficulty urinating, or may need to urinate all the time due to chronic bladder irritation. 2,8-DHA is also toxic to the kidneys and can lead to kidney failure.

Signs typically develop in adult dogs when stones have had the chance to develop.

The stones are not visible on radiographs, so ultrasound is required to visualize them. The stones must then be analyzed by a lab. Genetic testing is another way to detect the condition.

Treatment includes surgical removal or ablation of existing stones if they are interfering with your dog’s ability to urinate.

Talk to your vet about your dog’s 2,8-DHA urolithiasis result so you can work together to plan ongoing care and monitoring.

Your vet may recommend a low-purine diet or medications to help prevent urinary stone formation.

Make sure your dog has access to plenty of fresh water and regular opportunities to urinate, which can help reduce the risk of stones.

This mutation was first described in Native American Indian Dogs and one mixed breed.

Penetrance: This mutation is inherited in an autosomal recessive manner; that is, a dog requires two copies of the mutation to show signs of the disease.

Gene

APRT (Exon 3)

Inheritance type

recessive

Clinical category

Urinary

Citations

1. Furrow et al 2014

• American Indian Dog