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We test for 270+ genetic health risks. Learn how these conditions might affect dog health.

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Breeds Traits
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OFA

2,8-Dihydroxyadenine Urolithiasis, 2,8-DHA Urolithiasis

This condition leads to the formation of a specific type of kidney and bladder stone. These stones can irritate the urinary tract and may increase the risk of urinary discomfort or blockage.
  • Kidney and bladder
  • APRT

Achromatopsia

This condition affects cone cells in the retina, which are responsible for color and daylight vision. Affected dogs may have difficulty seeing in bright light.
  • Eyes
  • CNGA3 Exon 7, German Shepherd Variant

Achromatopsia

This condition affects cone cells in the retina, which are responsible for color and daylight vision. Affected dogs may have difficulty seeing in bright light.
  • Eyes
  • CNGA3 Exon 7, Labrador Retriever Variant

Alanine Aminotransferase Activity

ALT is a liver enzyme that vets measure to monitor liver health. With this result, your dog may naturally have a lower ALT baseline. Knowing this helps your veterinarian interpret future bloodwork results more accurately.
  • Clinical
  • GPT

Alaskan Husky Encephalopathy, Subacute Necrotizing Encephalomyelopathy

This neurologic condition affects how vitamin B1 is transported in the body. Because thiamine is essential for brain energy and nerve signaling, affected dogs can develop progressive neurologic signs.
  • Brain and spinal cord
  • SLC19A3

Alaskan Malamute Polyneuropathy, AMPN

This progressive neurologic condition affects peripheral nerves, which carry signals between the brain and the rest of the body. As these nerves are disrupted, dogs may develop weakness, coordination problems, and changes in movement or sensation.
  • Brain and spinal cord
  • NDRG1 SNP
Recommended by OFA

Alexander Disease

This neurologic condition affects astrocytes, supportive cells that help protect and nourish nerve cells in the brain. When these cells don’t function properly, normal brain support and signaling are disrupted, leading to neurologic problems.
  • Brain and spinal cord
  • GFAP

Autosomal Dominant Progressive Retinal Atrophy

This eye condition causes degeneration of the retina. Affected dogs typically lose night vision first, followed by progressive vision loss over time.
  • Eyes
  • RHO
Recommended by OFA

Autosomal Recessive Amelogenesis Imperfecta, Familial Enamel Hypoplasia

This condition affects how tooth enamel forms. Teeth may appear yellow, smaller, or more pointed than usual, with wider gaps between them due to uneven or reduced enamel coverage.
  • Other systems
  • ENAM Deletion, Italian Greyhound Variant
Recommended by OFA

Autosomal Recessive Amelogenesis Imperfecta, Familial Enamel Hypoplasia

This condition affects how tooth enamel forms. Teeth may appear yellow, smaller, or more pointed than usual, with wider gaps between them due to uneven or reduced enamel coverage.
  • Other systems
  • ENAM SNP, Parson Russell Terrier Variant

Autosomal Recessive Hereditary Nephropathy, Familial Nephropathy, ARHN

This progressive kidney condition affects the kidney’s filtering system, allowing protein to leak into the urine. Over time, this can lead to muscle loss, fluid buildup, and declining kidney function.
  • Kidney and bladder
  • COL4A4 Exon 30, English Springer Spaniel Variant

Autosomal Recessive Hereditary Nephropathy, Familial Nephropathy, ARHN

This disorder causes the kidneys to leak protein into urine, instead of keeping it in the bloodstream. Over time, this can lead to muscle loss, fluid retention, and a decline in kidney function.
  • Kidney and bladder
  • COL4A4 Exon 3, Cocker Spaniel Variant
Recommended by OFA

Bald Thigh Syndrome

This cosmetic condition causes hair loss on the thighs, commonly in Greyhounds. It results from changes in the hair follicles and does not typically affect a dog’s overall health.
  • Skin & connective tissues
  • IGFBP5

Benign Familial Juvenile Epilepsy, Remitting Focal Epilepsy

This form of epilepsy causes seizures in young dogs, often starting early in life. The seizures are usually temporary and tend to resolve on their own as the dog matures.
  • Brain and spinal cord
  • LGI2
Recommended by OFA

Bernard-Soulier Syndrome, BSS

This condition affects platelet function, making dogs more prone to bleeding. As their platelets don’t interact normally with clotting proteins, bleeding may be more noticeable after injury, surgery, or trauma.
  • Blood
  • GP9, Cocker Spaniel Variant

Canine Elliptocytosis

This is a benign condition that affects the shape of red blood cells. Instead of being round, the cells are more oval or elongated, and most dogs with this finding do not develop health problems.
  • Blood
  • SPTB Exon 30

Canine Fucosidosis

This condition affects how cells break down certain sugars, leading to the accumulation of waste within cells. Over time, this can lead to progressive neurologic signs as brain and nerve cells are affected.
  • Multisystem
  • FUCA1
Recommended by OFA

Canine Leukocyte Adhesion Deficiency Type I, CLAD I

This is a rare condition that affects white blood cell function, making it harder for the body to fight infections. As these cells don’t respond normally, affected dogs are more vulnerable to serious illness.
  • Blood
  • ITGB2, Setter Variant
Recommended by OFA

Canine Leukocyte Adhesion Deficiency Type III, CLAD III

This is a rare condition that affects white blood cells and platelets, making it harder to fight infections and control bleeding. As these cells don’t respond normally, affected dogs are more vulnerable to serious illness and bleeding.
  • Blood
  • FERMT3, German Shepherd Variant
Recommended by OFA

Canine Multifocal Retinopathy, cmr1

This condition causes spots on the retina but is not progressive, meaning it usually doesn’t worsen. Most dogs keep their vision, though larger areas can affect sight. New spots typically stop forming by adulthood, and some may even improve over time.
  • Eyes
  • BEST1 Exon 2
Recommended by OFA

Canine Multifocal Retinopathy, cmr2

This condition causes spots on the retina but is not progressive, meaning it usually doesn’t worsen. Most dogs keep their vision, though larger areas can affect sight. New spots typically stop forming by adulthood, and some may even improve over time.
  • Eyes
  • BEST1 Exon 5, Coton de Tulear Variant
Recommended by OFA

Canine Multifocal Retinopathy, cmr3

This condition causes spots on the retina but is not progressive, meaning it usually doesn’t worsen. Most dogs keep their vision, though larger areas can affect sight. New spots typically stop forming by adulthood, and some may even improve over time.
  • Eyes
  • BEST1 Exon 10 Deletion, Finnish and Swedish Lapphund, Lapponian Herder Variant

Cardiomyopathy and Juvenile Mortality

This condition affects the heart early in life, causing it to become enlarged and weakened. In some cases, it can lead to sudden death in puppies, often within the first few weeks of age.
  • Heart
  • YARS2

Centronuclear Myopathy, CNM

This muscle disorder affects strength and endurance. Affected dogs may tire easily, lose weight, and develop muscle wasting over time as muscle fibers are damaged and gradually replaced with scar tissue.
  • Muscular
  • PTPLA
Recommended by OFA

Cerebellar Abiotrophy, Neonatal Cerebellar Cortical Degeneration, NCCD

This disorder impacts the cerebellum, which helps fine-tune movement, balance, and coordination. When it doesn’t function properly, dogs may appear unsteady, uncoordinated, or have trouble with precise movements.
  • Brain and spinal cord
  • SPTBN2, Beagle Variant
Recommended by OFA

Cerebellar Ataxia, Progressive Early-Onset Cerebellar Ataxia

This disorder impacts the cerebellum, which helps fine-tune movement, balance, and coordination. When it doesn’t function properly, dogs may appear unsteady, uncoordinated, or have trouble with precise movements.
  • Brain and spinal cord
  • SEL1L, Finnish Hound Variant

Cerebellar Hypoplasia

This disorder impacts the cerebellum, which helps fine-tune movement, balance, and coordination. When it doesn’t function properly, dogs may appear unsteady, uncoordinated, or have trouble with precise movements.
  • Brain and spinal cord
  • VLDLR, Eurasier Variant

Chondrodysplasia

This describes a body type with shorter limbs and a proportionally longer body. It is common in some breeds, and dogs with this build typically remain healthy and active.
  • Skeletal
  • ITGA10, Norwegian Elkhound and Karelian Bear Dog Variant
Recommended by OFA

Chondrodystrophy and Intervertebral Disc Disease, CDDY/IVDD, Type I IVDD

This condition is associated with differences in body proportions, such as a longer back and shorter legs, and may increase the risk of spinal disc problems. Disc disease can vary in severity, from mild discomfort to more serious movement changes.
  • Skeletal
  • FGF4 retrogene - CFA12
Recommended by OFA

Cleft Lip and/or Cleft Palate

This developmental condition occurs when parts of the lip or roof of the mouth don’t fully fuse before birth. Depending on the area affected, dogs may have a cleft lip, a cleft palate, or both.
  • Skeletal
  • ADAMTS20, Nova Scotia Duck Tolling Retriever Variant
Recommended by OFA

Cleft Palate, CP1

This developmental condition occurs when parts of the lip or roof of the mouth don’t fully fuse before birth. Depending on the area affected, dogs may have a cleft lip, a cleft palate, or both.
  • Skeletal
  • DLX6 intron 2, Nova Scotia Duck Tolling Retriever Variant
Recommended by OFA

Collie Eye Anomaly, Choroidal Hypoplasia, CEA

This eye condition affects normal eye development. Severity varies, and while some dogs have mild changes, others may have vision impairment.
  • Eyes
  • NHEJ1
Recommended by OFA

Complement 3 Deficiency, C3 Deficiency

This condition affects the immune system’s ability to fight infections. Dogs may be more susceptible to recurrent bacterial infections due to impaired immune defense.
  • Immune
  • C3

Congenital Cornification Disorder

This rare skin condition causes painful, thickened patches of hairless, darkened skin that often appear in lines. When lesions occur on the legs, they can be uncomfortable and may lead to limping.
  • Skin & connective tissues
  • NSDHL, Chihuahua Variant

Congenital Dyserythropoietic Anemia and Polymyopathy

This condition affects red blood cell production and muscle function. Affected dogs may have small red blood cells, weakness in the hind legs due to muscle loss, and episodes of regurgitation.
  • Multisystem
  • EHPB1L1, Labrador Retriever Variant

Congenital Dyshormonogenic Hypothyroidism with Goiter

This condition affects thyroid development or hormone production from birth. When thyroid hormones are low, dogs may have slowed growth and low energy, and some may develop an enlarged thyroid gland called a goiter.
  • Hormones
  • SLC5A5, Shih Tzu Variant

Congenital Hypothyroidism

This condition affects thyroid hormone production from birth. Affected dogs may show slowed growth, low energy, and developmental delays, but many improve with early diagnosis and treatment.
  • Hormones
  • TPO, Tenterfield Terrier Variant

Congenital Hypothyroidism

This condition affects thyroid hormone production from birth. Affected dogs may show slowed growth, low energy, and developmental delays, but many improve with early diagnosis and treatment.
  • Hormones
  • TPO, Rat, Toy, Hairless Terrier Variant
Recommended by OFA

Congenital Hypothyroidism with Goiter

This condition affects thyroid hormone production and causes thyroid gland enlargement. That enlargement is called a goiter and may show up in your dog as a swelling in the neck, along with lower energy and growth delays.
  • Hormones
  • TPO Intron 13, French Bulldog Variant

Congenital Keratoconjunctivitis Sicca and Ichthyosiform Dermatosis, Dry Eye Curly Coat Syndrome, CKCSID

This condition affects the development of the eyes, skin, hair, and nails. Affected dogs may have dry eyes, corneal ulcers, itchy skin, and thick or cracked paw pads.
  • Multisystem
  • FAM83H Exon 5
Recommended by OFA

Congenital Macrothrombocytopenia

This is a benign condition that affects platelet production, leading to platelets that are fewer in number and larger in size than usual. Most dogs with this finding do not develop related health problems.
  • Blood
  • TUBB1 Exon 1, Cairn and Norfolk Terrier Variant

Congenital Muscular Dystrophy

This condition affects a protein that helps keep muscle fibers stable. When the protein is reduced or absent, muscles are more easily damaged, leading to progressive muscle weakness and wasting over time.
  • Muscular
  • LAMA2, Italian Greyhound

Congenital Myasthenic Syndrome, CMS

This condition affects how nerves communicate with muscles. Affected dogs may have episodes of weakness or fatigue with exercise, but the condition should not worsen over time.
  • Neuromuscular
  • CHAT, Old Danish Pointing Dog Variant

Congenital Myasthenic Syndrome, CMS

This condition affects how nerves communicate with muscles. Affected dogs may have episodes of weakness or fatigue with exercise, but the condition should not worsen over time.
  • Neuromuscular
  • CHRNE, Jack Russell Terrier Variant

Congenital Myasthenic Syndrome, CMS

This condition affects how nerves communicate with muscles. Affected dogs may have episodes of weakness or fatigue with exercise, but the condition should not worsen over time.
  • Neuromuscular
  • COLQ, Golden Retriever Variant

Congenital Myasthenic Syndrome, CMS

This condition affects how nerves communicate with muscles. Affected dogs may have episodes of weakness or fatigue with exercise, but the condition should not worsen over time.
  • Neuromuscular
  • COLQ, Labrador Retriever Variant

Congenital Stationary Night Blindness

This condition affects how well dogs see in dim light, often causing night blindness. In some cases, vision loss can worsen over time. It is caused by changes in the retina and the tissue that helps support and protect it.
  • Eyes
  • RPE65, Briard Variant
Recommended by OFA

Congenital Stationary Night Blindness

This condition affects how well dogs see in dim light, often causing night blindness. In some cases, vision loss can worsen over time. It is caused by changes in the retina and the tissue that helps support and protect it.
  • Eyes
  • LRIT3, Beagle Variant

Copper Toxicosis (Accumulating)

This condition affects the liver’s ability to remove excess copper. Over time, copper can build up in the liver and damage liver cells. Both genetic and environmental factors play a role in how the condition develops.
  • Liver
  • ATP7B
Recommended by OFA

Copper Toxicosis (Attenuating)

This genetic variant may help lessen the effects of copper buildup in dogs that also carry the copper toxicosis risk variant ATP7B. On its own, it is not known to cause health problems.
  • Clinical
  • ATP7A, Labrador Retriever
Recommended by OFA

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