Canine Leukocyte Adhesion Deficiency Type I, CLAD I

Affected dogs may have recurrent, severe skin infections (pyoderma), limping (lameness), and/or swollen, bleeding gums (gingivitis). They may also have prominent lymph nodes that are easily felt under the jaw, on the chest, and on the hind legs.

This disease is typically diagnosed in puppies when they fail to grow, have umbilical infections, and/or swollen lymph nodes. They may also experience chronic infections following a spay or neuter.

Genetic or laboratory tests are performed to diagnose this condition.

Currently, treatment for CLAD I focuses on symptomatic management. Judicious, chronic antibiotic use is typically required.

Talk to your vet about your dog’s CLAD result, as it may influence how they monitor your dog’s health and prepare for any surgeries or procedures.

Practice good hygiene, including regular bathing with a gentle or antiseptic shampoo and routine dental care, to help reduce infection risk.

Be cautious with activities that could cause injury, like rough play at dog parks or off-leash hikes, and seek prompt veterinary care for any wounds, illnesses, or signs of infection.

This variant was first identified in Irish Setters.

Penetrance: CLAD I is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.

Gene

ITGB2 Exon 3

Inheritance type

recessive

Clinical category

Hematologic

Citations

1. Kijas et al 1999

• Irish Red and White Setter
• Irish Setter