Canine Multifocal Retinopathy, cmr2

Most dogs affected with CMR show no clinical signs. Mild vision loss may be apparent in the worst cases and include bumping into walls and a reduced ability to track toys or other objects.

cmr2 typically develops in puppies at 14 to 16 weeks and becomes stable by the time they are 1 year old.

CMR is typically only identified when a vet examines the back of the eye which, in dogs with CMR, reveals multiple retinal abnormalities that range from small, flat folds (called "retinal folds") to larger, irregularly edged raised lesions (called "geographic lesions").

Currently, there is no treatment for CMR. However, CMR rarely affects vision to a significant degree, and as we stated, even the associated retinal abnormalities can regress over time.

Talk to your vet about your dog’s CMR result so you can work together to plan their ongoing care and monitoring.

Schedule regular eye exams with your vet or a veterinary ophthalmologist to monitor for changes in your dog’s vision.

If you notice any changes in your dog’s eyesight or comfort, such as bumping into objects or hesitating in bright light, contact your vet for guidance.

This mutation was first identified in the Coton de Tulear.

Penetrance: CMR is inherited in an autosomal recessive manner. Dogs must have two copies of the mutation to show clinical signs.

Gene

BEST1/VMD2 Exon 5

Inheritance type

recessive

Clinical category

Ophthalmologic

Citations

1. Guziewicz et al 2007
2. http://omia.org/OMIA001553/9615/

• Coton de Tulear