Copper Toxicosis (Attenuating)

There should be no clinical signs associated with this variant. This variant may help mitigate clinical signs in dogs with the ATP7B accumulating variant. If your dog has the ATP7B variant, please read about possible clinical signs on the ATP7B page.

A variant in this gene may delay or have no effect on the onset of clinical signs of copper toxicosis in dogs with the ATP7B variant. If your dog has the ATP7B variant, please read more about the age of onset on the ATP7B page.

No diagnostics are required for this variant. If your dog has the ATP7B variant, please read what diagnostics may be considered on the ATP7B page.

No treatment is required for this variant. If your dog has the ATP7B variant, please read the available treatment on the ATP7B page.

No specific action is needed for dogs with this variant alone.

If your dog also has the ATP7B variant, please review what actions you can take on the ATP7B page.

Routine veterinary care and a balanced diet are appropriate for most dogs with this result.

This mutation was first described in the Labrador Retriever. However, it has recently been studied in the Doberman Pinscher and may also benefit this breed.

Penetrance: This variant has a X-linked complex inheritance. This variant has been shown to decrease copper accumulation in dogs with one or two copies of the ATP7B variant but is more effective in male dogs. However, this variant is not completely protective in either sex.

Gene

ATP7A

Inheritance type

X-linked complex

Clinical category

Clinical

Citations

1. Feiten et al 2016
2. Wu et al 2019
3. Langlois et al 2022

• English Labrador Retriever
• Labrador Retriever
• Doberman Pinscher