Copper Toxicosis (Attenuating)

There should be no clinical signs associated with this variant. This variant may help mitigate clinical signs in dogs with the ATP7B accumulating variant. If your dog has the ATP7B variant, please read about possible clinical signs on the ATP7B page.

A variant in this gene may delay or not affect the onset of clinical signs of copper toxicosis in dogs with the ATP7B variant. If your dog has the ATP7B variant, please read more about the age of onset on the ATP7B page.

No diagnostics are required for this variant. If your dog has the ATP7B variant, please read what diagnostics may be considered on the ATP7B page.

No treatment is required for this variant. If your dog has the ATP7B variant, please read the available treatment on the ATP7B page.

No specific action is needed for dogs with this variant alone.

If your dog also has the ATP7B variant, please review what actions you can take on the ATP7B page.

Routine veterinary care and a balanced diet are appropriate for most dogs with this result.

This mutation was first described in the Labrador Retriever.

Penetrance: This variant has a complex inheritance. This variant may decrease copper accumulation in dogs with one or two copies of the ATP7B variant, but should not be considered fully protective.

Gene

RETN Exon 2

Inheritance type

complex

Clinical category

Clinical

Citations

1. Wu et al 2020
2. Feiten et al 2016
3. Wu et al 2019
4. Langlois et al 2022

• Labrador Retriever
• English Labrador Retriever