Cystinuria Type II-B

Affected dogs will show no clinical signs of disease in the early stages. As stones form, dogs will often urinate more frequently, urinate in inappropriate places, and possibly have blood in their urine. If a urinary obstruction forms, they are unable to urinate despite frequent straining. This is a medical emergency.

Signs typically develop in adult dogs when stones have had the chance to develop.

Genetic and laboratory testing are used to diagnose this condition.

If caught early, Cystinuria can be managed with dietary changes, increased water intake, and certain medications. If stones develop, surgical removal is often necessary.

Talk to your vet about your dog’s cystinuria result so you can work together to plan ongoing care and monitoring.

Schedule regular checkups and lab testing as recommended to detect any urinary changes early.

Your vet may recommend a special diet to help reduce cystine levels and prevent urinary stone formation.

Encourage your dog to drink plenty of water and watch for changes in urination, such as straining, accidents, or blood in the urine. Contact your vet if you notice any of these signs.

This mutation was first described in the Miniature Pinscher.

Penetrance: This mutation is inherited in an autosomal dominant manner, meaning that one or two copies of this gene will cause the disorder.

Gene

SLC7A9 (Exon 9)

Inheritance type

dominant

Clinical category

Urinary

Citations

1. Brons et al 2013

• Miniature Pinscher