Dental-Skeletal-Retinal Anomaly

Affected dogs are smaller than their littermates, with short and angularly bent limbs. Their puppy teeth are translucent and easily break. Their adult teeth can be discolored pink or brown with defects in the enamel. As they age, their vision worsens

Signs can first be recognized in puppies.

A complete physical examination, including an oral exam, is needed to assess any changes in the limbs and teeth. Diagnosis of any vision changes requires an eye exam to visualize the retina.

Currently, DSRA cannot be treated, only managed.

Talk to your vet about your dog’s dental skeletal retinal anomaly result so you can discuss any vision or dental changes and plan appropriate monitoring.

Dogs with this condition may have reduced vision, so use verbal cues and a consistent routine to help them navigate safely.

Practice regular dental care, including brushing your dog's teeth with dog-safe toothpaste, and schedule periodic dental checkups to maintain your dog's oral health.

This variant was first described in the Cane Corso.

Penetrance: This variant is inherited in an autosomal recessive manner, meaning that a dog requires two copies of the variant to show signs of DSRA.

Gene

MIA3 Intron 9

Inheritance type

recessive

Clinical category

Skeletal

Citations

1. Christen et al 2021

• Cane Corso