Focal Non-Epidermolytic Palmoplantar Keratoderma, Pachyonychia Congenita

Painful thickening of the footpads is the first sign most owner's recognize.

This is often first recognized in juvenile dogs.

Clinical signs, genetic testing, and biopsy can be used to diagnose this condition.

Cracks in the foot pads make dogs more likely to contract a secondary bacterial infection, which can be managed with appropriate antibiotics; treatment of the foot pads with softening soaks can also reduce pain associated with the condition.

Talk to your vet about your dog’s palmoplantar keratoderma result so you can plan appropriate care and monitoring.

Keep your dog’s paw pads moisturized and avoid rough or abrasive surfaces that could cause cracking or discomfort. Use gentle, dog-safe paw balms or protective booties, especially for long walks or hard terrain.

If you notice limping, bleeding, or signs of infection, contact your vet promptly for treatment and pain relief.

It has been mapped to the KRT16 gene in the Dogue de Bordeaux.

Penetrance: This mutation has an autosomal recessive inheritance, meaning that dogs must have two copies of the mutation in order to show clinical signs.

Gene

KRT16 (Exon 6)

Inheritance type

recessive

Clinical category

Integument

Citations

1. Plassais et al 2015

• Dogue de Bordeaux