Hereditary Footpad Hyperkeratosis

Painful thickening of the footpads is the first sign most owner's recognize.

Signs first appear in puppies around 8 weeks of age.

Clinical signs, genetic testing, and biopsy can be used to diagnose this condition.

Cracks in the foot pads make dogs more likely to contract a secondary bacterial infection, which can be managed with appropriate antibiotics; treatment of the foot pads with softening soaks can also reduce pain associated with the condition.

Talk to your vet about your dog’s hereditary footpad hyperkeratosis result so you can plan appropriate care and monitoring.

Keep your dog’s paw pads moisturized and avoid rough or abrasive surfaces that could cause cracking or pain. Regular use of dog-safe paw balms or protective booties can help prevent irritation, especially during long walks or in extreme temperatures.

If you notice limping, bleeding, or signs of infection, contact your vet promptly for treatment and pain relief.

This mutation was first described in a Rottweiler.

Penetrance: This mutation has an autosomal recessive inheritance, meaning that dogs must have two copies of the mutation in order to show clinical signs.

Gene

DSG1

Inheritance type

recessive

Clinical category

Integument

Citations

1. Backel et al 2020

• Rottweiler