Lagotto Storage Disease

Ataxia, behavioral changes, and abnormal eye movements can be seen with this disorder.

Signs can have a juvenile (4 months) to adult (4 years) onset.

Genetic and laboratory testing used to diagnose this disease.

There is no treatment except supportive care for the clinical signs the affected dog develops.

Talk to your vet about your dog’s Lagotto storage disease result so you can work together to plan ongoing care and monitoring.

Schedule regular checkups to monitor for changes in mobility, coordination, or behavior.

Work with your vet to provide supportive care that keeps your dog comfortable and helps them stay active and engaged.

Help your dog feel secure by keeping furniture in familiar places, using non-slip mats, and maintaining predictable daily routines.

This mutation was first described in the Lagotto Romagnolo.

Penetrance: This mutation is inherited in an autosomal recessive manner; that is, a dog requires two copies of the mutation to show signs of the disease.

Gene

ATG4D (Exon 10)

Inheritance type

recessive

Clinical category

Multisystem

Citations

1. Kyostila et al 2015

• Lagotto Romagnolo