Ligneous Membranitis, LM

Affected dogs often have chronic nasal discharge, conjunctivitis, and coughing.

Signs typically develop in puppies.

Genetic and laboratory testing along with clinical signs are used to diagnose this disease.

LM is a devastating disease and requires aggressive and continuous replacement of plasminogen with medically available blood products. Euthanasia is often elected.

Talk to your vet about your dog’s ligneous membranitis result, as it may influence how they approach diagnostics and monitor your dog’s health over time.

Schedule regular checkups and let your vet know right away if you notice any signs such as eye irritation, discharge, or changes in your dog’s mouth or breathing.

This mutation was first described in the Scottish Terrier.

Penetrance: This disease is inherited in an autosomal recessive manner, meaning that a dog must have two copies of the mutation to be affected.

Gene

PLG

Inheritance type

recessive

Clinical category

Hematologic

Citations

1. Ainsworth et al 2015

• Scottish Terrier