Mucopolysaccharidosis Type IIIA, Sanfilippo Syndrome Type A, MPS IIIA

Affected dogs are ataxic, have abnormal eye movements, and head tremors.

Signs typically develop around 18 months of age, and most dogs do not survive more than a few months after diagnosis.

Genetic and laboratory testing used to diagnose this disease.

There is no treatment except supportive care for the clinical signs the affected dog develops.

Talk to your vet about your dog’s mucopolysaccharidosis result so you can work together to plan ongoing care and monitoring.

Schedule regular checkups to monitor for changes in mobility, coordination, or behavior.

Work with your vet to provide supportive care that keeps your dog comfortable and helps them stay active and engaged.

Help your dog feel secure by keeping furniture in familiar places, using non-slip mats, and maintaining predictable daily routines.

This mutation was first described in the New Zealand Huntaway.

Penetrance: This mutation is inherited in an autosomal recessive manner; that is, a dog requires two copies of the mutation to show signs of the disease.

Gene

SGSH

Inheritance type

recessive

Clinical category

Multisystem

Citations

1. Yogalingam et al 2002

• New Zealand Huntaway