Myasthenia Gravis-Like Syndrome

Affected puppies had poor coordination, decreased reflexes and collapse.

Signs first appear in young puppies.

Genetic testing, blood work, neurological tests, and clinical signs can be used to diagnose this condition.

This is a lifelong condition that showed poor response to medical treatments.

Talk to your vet about your dog’s myasthenia gravis–like syndrome result so you can plan appropriate monitoring and care.

Avoid known triggers such as overexertion, stress, or excitement, which can worsen muscle weakness.

Watch for signs like a drooping head, difficulty walking, or changes in swallowing, and contact your vet if you notice them.

With consistent management and a calm, predictable routine, many dogs with this condition can remain comfortable and active.

This mutation was first described in the Heideterrier.

Penetrance: This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.

Gene

CHRNE

Inheritance type

recessive

Clinical category

Neuromuscular

Citations

1. Herder et al 2017

• Heideterrier