Oculoskeletal Dysplasia 2, Dwarfism-Retinal Dysplasia 2, drd2, OSD2

Signs can include dramatic short-limbed dwarfism, lameness, and partial to complete vision loss. Affected dogs tend to have early onset arthritis.

Signs are first recognized in puppies.

Genetic testing and clinical signs can be used to diagnose this condition.

Currently, there is no treatment for this condition. Medications may be prescribed to help with pain.

Talk to your vet about your dog’s OSD2 result so you can discuss whether any signs are present and plan care if needed.

Some dogs show only mild limb shortening and live normal, active lives, while others may need extra support for mobility or vision changes.

Provide soft bedding, nonslip flooring, and ramps if your dog has trouble getting around, and avoid activities like jumping or climbing stairs that could stress the joints.

If you notice signs of vision loss, keep your dog on a leash in unfamiliar areas and use verbal cues to help them navigate safely.

This mutation was first described in the Samoyed.

Penetrance: This mutation has an autosomal recessive inheritance, meaning that dogs must have two copies of the mutation in order to show clinical signs.

Gene

COL9A2 (5' UTR)

Inheritance type

recessive

Clinical category

Skeletal

Citations

1. Goldstein et al 2010

• Samoyed
• Samoyed (Landrace)