Platelet Factor X Receptor Deficiency, Scott Syndrome

If your affected dog suffers a major trauma or undergoes surgery, they may not be able to clot well leading to increased blood loss or internal bleeding.

Dogs are born with this condition.

Genetic and laboratory testing can be used to diagnose this disorder.

There is no cure for this condition. Dogs with this disease may need blood/platelet transfusions during surgery or following a major trauma. However, they should have a normal lifespan.

Talk to your vet about your dog’s Scott syndrome result before any surgeries or dental procedures, as it may influence how they prepare.

Many dogs with this result never show symptoms or develop health problems related to this variant.

This mutation was first identified in the German Shepherd Dog.

Penetrance: This disease is inherited in an autosomal recessive manner, meaning that a dog must have two copies of the mutation to be affected.

Gene

TMEM16F

Inheritance type

recessive

Clinical category

Hematologic

Citations

1. Brooks et al 2015

• Berger Blanc Suisse
• Czechoslovakian Vlcak
• German Shepherd Dog
• King Shepherd
• Saarloos Wolfdog
• Shiloh Shepherd
• White Shepherd