Polycystic Kidney Disease, PKD

You may notice your dog has abdominal pain and is drinking and urinating excessively. Severe loss of kidney function is characterized by vomiting, lethargy, neurologic behavior, and the inability to produce urine (anuria).

PKD has an adult onset.

Genetic and laboratory testing are used to diagnose this condition. An abdominal ultrasound can visualize the cysts in the kidneys.

There is no treatment for PKD. Management of the kidney disease includes giving a prescription diet, supplemental fluids, and medications to control the symptoms.

Talk to your vet about your dog’s PKD result so you can work together to plan ongoing care and monitoring.

Schedule regular checkups and lab testing as recommended to monitor kidney function and detect any changes early.

Your vet may suggest a kidney-friendly diet and hydration plan to help support long-term kidney health.

Watch for changes in drinking or urination habits, such as increased thirst, accidents, or changes in urine volume, and contact your vet if you notice any of these signs.

This mutation was first described in the Bull Terrier.

Penetrance: This mutation is inherited in an autosomal dominant manner, meaning that one or two copies of this gene will cause the disorder.

Gene

PKD1 (Exon 29)

Inheritance type

dominant

Clinical category

Urinary

Citations

1. Gharahkhani et al 2011

• Bull Terrier