Prekallikrein Deficiency

Affected dogs have abnormally long clotting times on laboratory coagulation tests, but this does not lead to an increased bleeding risk clinically.

Dogs are born with this disorder, but it is often not recognized unless your veterinarian performs certain blood tests.

Genetic testing and laboratory clotting times are used to diagnose this condition.

At this time, no treatment is required for dogs with this genetic mutation.

Talk to your vet about your dog’s prekallikrein deficiency result, as it may influence how they interpret bloodwork or clotting tests.

Many dogs with this result never show symptoms or develop health problems related to this variant.

This mutation was first identified in a Shih Tzu.

Penetrance: Dogs must have two copies of the mutation for their prekallikrein levels to be affected.

Gene

KLKB1 Exon 8

Inheritance type

recessive

Clinical category

Hematologic

Citations

1. Okawa et al 2011

• Shih Tzu