Primary Hyperoxaluria

Affected dogs may have excessive thirst and urination and strain while urinating. If in kidney failure, they may not be able to produce urine, vomit, and be lethargic.

Signs are often first noted in puppies.

Genetic and laboratory testing are used to diagnosis this disorder.

If diagnosed early, this disorder can be managed with dietary and lifestyle changes. However, if a puppy presents in kidney failure, aggressive treatment including hospitalization will be required and the puppy will have a poor prognosis.

Talk to your vet about your dog’s primary hyperoxaluria result so you can work together to plan ongoing care and monitoring.

Your vet may recommend a special diet to help reduce oxalate levels and prevent urinary stone formation.

Make sure your dog has access to plenty of fresh water and regular opportunities to urinate.

Watch for changes in urination, such as straining, accidents, or blood in the urine, and contact your vet if you notice any of these signs.

This mutation was first described in the Coton de Tulear.

Penetrance: This mutation is inherited in an autosomal recessive manner; that is, a dog requires two copies of the mutation to show signs of the disease.

Gene

AGXT (Exon 2)

Inheritance type

recessive

Clinical category

Urinary

Citations

1. Vidgren et al 2012

• Coton de Tulear