Pyruvate Dehydrogenase Deficiency

Affected dogs have extreme exercise intolerance.

Signs are often first apparent in juveniles.

Genetic testing and clinical signs can be used to diagnose this condition.

Dietary changes are typically recommended and involve a high fat, high protein diet. These energy sources don't require pyruvate dehydrogenase for processing. Please speak to your veterinarian before changing your dog's diet.

Talk to your vet about your dog’s pyruvate dehydrogenase deficiency result so you can plan appropriate monitoring and care.

Follow your vet’s nutritional recommendations carefully, as dietary adjustments can help support energy metabolism.

Watch for signs such as fatigue, weakness, or reluctance to exercise, and contact your vet if you notice any of these.

Provide a calm, predictable routine to help your dog conserve energy and stay comfortable.

This mutation was first characterized in the Sussex and Clumber Spaniels.

Penetrance: This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.

Gene

PDP1

Inheritance type

recessive

Clinical category

Metabolic

Citations

1. Cameron et al 2007

• Clumber Spaniel
• Sussex Spaniel