Severe Combined Immunodeficiency, SCID
SCID dogs cannot produce functional B-lymphocytes, the cells responsible for producing antibodies and long-term "memory" of infection, as well as T-lymphocytes, which can act to destroy infected cells as well as direct other immune cells to do their job. In the absence of a functional immune system, they are extremely susceptible to infections.
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Signs and symptoms
Affected dogs are extremely susceptible to infections: bacterial, viral and parasitic. Affected puppies are often lethargic with poor growth.
Most SCID dogs are identified as puppies soon after weaning or when initially vaccinated with modified live products.Uncover health risks with Embark
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Diagnosis
Genetic and laboratory testing along with clinical signs are used to diagnose this disease.
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Treatment
Identifying the type of infection and giving appropriate medication is the only treatment currently available. Dogs with this condition often have a markedly shortened lifespan.
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What to do if your dog is at risk
Actions
- Talk to your vet about your dog’s SCID result so you can work together to plan their ongoing care and monitoring.
- Work closely with your vet to prevent and manage infections through regular checkups, good hygiene, and prompt care if your dog becomes ill.
- Be cautious with activities that could cause injury or expose your dog to sources of infection, such as crowded dog parks or boarding facilities.
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Genetic Information
This mutation was first described in Frisian Water Dogs.
This condition is inherited in an autosomal recessive manner, meaning that a dog must have two copies of the mutation to be affected.
Gene names:
RAG1 ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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