Primary Lens Luxation

ADAMTS17

Eyes

This condition affects the ligaments that hold the lens in place, allowing it to shift within the eye. It can cause pain and vision problems and often requires prompt treatment.

Signs and symptoms

You can visually appreciate the lens luxation by peeking in your dog's pupil: almost always, the dislodged lens can be seen as a clear half moon either in front of or in back of the iris. Your dog may also show signs of ocular irritation and pain.

Signs of this disease typically first appear in adulthood (3-8 years on average).

Diagnosis

Treatment

What to do if your dog is at risk

Talk to your vet about your dog’s PLL result so you can work together to plan regular eye exams and monitoring.

Schedule veterinary eye exams to check for early signs of lens movement or instability and discuss whether referral to a veterinary ophthalmologist may be helpful.

Watch for eye changes such as cloudiness, redness, squinting, or pawing at the eye, and contact your vet right away if you notice any of these signs.

Genetic information

This mutation was first identified in the Jack Russell Terrier, Lancashire Heeler, and the Miniature Bull Terrier.

Penetrance: This mutation has an additive genetic effect, meaning that while dogs with one copy of the mutation can develop PLL, they have a much lower risk than dogs with two copies of the mutation.

Gene: ADAMTS17
Inheritance type: additive
Clinical category: Ophthalmologic