Raine Syndrome, Canine Dental Hypomineralization Syndrome

Worn teeth that may have cracks, display discolored enamel, or exposed pulp can be seen in affected dogs.

Signs are often first recognized in adults.

Genetic testing and clinical signs can be used to diagnose this condition.

Routine dental treatments including tooth extraction is used to manage this disease.

Talk to your vet about your dog’s Raine syndrome result so you can plan appropriate dental care, including regular professional cleanings and exams to monitor for signs of tooth wear or damage.

Brush your dog’s teeth regularly using a soft-bristled brush and dog-safe toothpaste to reduce plaque and protect weakened enamel.

Avoid hard toys, bones, or treats that could chip or crack fragile teeth.

This mutation was first described in the Border Collie.

Penetrance: This mutation has an autosomal recessive inheritance, meaning that dogs must have two copies of the mutation in order to show clinical signs.

Gene

FAM20C

Inheritance type

recessive

Clinical category

Skeletal

Citations

1. Hytonen et al 2016

• Border Collie