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Multisystem

This is a Multisystem condition.

Canine Fucosidosis

What is Fucosidosis?

This form of lysosomal storage disease can cause progressive neurologic dysfunction. Lysosomes are highly specialized organelles: their job is to digest and recycle cellular waste, including engulfed molecules or microorganisms, byproducts of cellular metabolism, and old or degrading organelles. Lysosomes are known to contain over 50 enzymes (the proteins that do the digesting); lysosomal storage disease arises when there is a malfunction in any of these enzymes. The hallmark of lysosomal storage disease is the microscopic appearance of the lysosomes: they appear enlarged and swollen with undigested byproducts. The buildup of undigested byproducts can eventually lead to lysosomal, cell, tissue, and organ malfunction. Fucosidosis is specifically a buildup of fucose-containing sugar and sugar derivatives--onset of signs between 1 and 4 years of age. Common signs of fucosidosis include progressive central nervous system malfunction, difficulty eating, subsequent weight loss, partial or total vision loss, behavior changes, abnormal gait, and seizures.

What are the signs & symptoms that develop in affected dogs?

Common signs of fucosidosis include progressive central nervous system malfunction, difficulty eating, subsequent weight loss, partial or total vision loss, behavior changes, abnormal gait, and seizures.

When do signs and symptoms develop?

Onset of signs is typically between 1 and 4 years of age.

How do vets diagnose this condition?

Genetic and laboratory testing are used to diagnose this condition. MRI or CT scans may be recommended to rule out other neurologic diseases.

How is this condition treated?

There is no treatment for fucosidosis, and it is a fatal disease.

What actions should I take if my dog is affected?

Focus on palliative therapies to increase your dog's comfort and quality of life.

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