Congenital Cornification Disorder
Congenital Cornification Disorder is a rare, inherited skin disease causing lesions that are often in a linear pattern. Affected skin is hairless, thickened, and darkly pigmented. The lesions are very painful and can cause limping if they are on a dog's leg.
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Signs and symptoms
Affected dogs have hairless patches of skin, often in a linear pattern. These areas have clearly defined borders. The skin lesions can be thickened, darkly pigmented, and very painful. If these lesions are present on a dog's leg, they can cause limping.
Skin lesions develop in dogs less than one year of age. -
Diagnosis
This condition can be diagnosed using a combination of a skin biopsy and genetic testing.
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Treatment
Your veterinarian may try several treatment options before finding the most effective one. Treatment usually entails prescription shampoo with an antibiotic and anti-inflammatory cream.
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What to do if your dog is at risk
Actions
- Discuss treatment options with your veterinarian and follow their instructions consistently.
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Genetic Information
This variant was first described in the Chihuahua.
This variant is inherited in an X-linked dominant manner, meaning that a dog only requires one copy of the variant to show signs of Congenital Cornification Disorder. Male dogs with one copy of the variant and female dogs with two copies of the variant likely do not survive to birth.
Gene names:
NSDHL Exon 8 ‐ chr
Inheritance type:
dominant
Citations:
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Breeds affected
This health condition affects the following breeds
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