Dry Eye Curly Coat Syndrome


A developmental disease of the eyes, skin, hair, and nails, dogs affected with this condition are prone to corneal ulcers, itchy skin, and thick, cracked paw pads.

  • Signs and symptoms

    CKCSICD puppies are born with an unusually rough, curly hair coat and do not produce tears, which leads to the early symptoms of corneal ulcers, infection, and ocular discharge. As pups grow, you may also notice that their paw pads are especially thick and crusty (hyperkeratotic) and that their nails appear malformed. Over time, the paw pads can crack and slough, causing pain and lameness. The adult hair coat grows in rough, sparse, and frizzy, and the "ichthyotic" skin scaling causes thickened, darkened skin, especially around the belly area. In adulthood, it has been noted that CKCSICD dogs have a higher incidence of dental disease.

    Affected dogs are often first noted at birth, although signs continue to develop into adulthood.

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  • Diagnosis

    Genetic and laboratory testing are used to diagnosis this disorder.

  • Treatment

    The symptoms of CKCSICD can be managed with artificial tears and antibiotics as needed for infected corneal ulcers, soothing baths for itchy skin, and conditioning creams for thick paw pads. Regular dental check ups are recommended for all adult dogs.

  • What to do if your dog is at risk


    • Please follow your veterinarian's advice and give medication appropriately.

  • Genetic Information

    This mutation was first described in the Cavalier King Charles Spaniel.

    This mutation is inherited in an autosomal recessive manner; that is, a dog requires two copies of the mutation to show signs of the disease.

    Gene names:

    FAM83H ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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