Hereditary Nasal Parakeratosis

skin & connective tissue

The epidermis (outermost skin layer) of the canine nasal planum (the exterior of the nose) is on average more than twice the thickness of haired skin in healthy dogs. Hereditary Nasal Parakeratosis (HNPK) is a localized condition of the nasal planum leading to crusts and fissures on the surface.

  • Signs and symptoms

    Clinical signs range from mild to more severe lesions and may wax and wane during a dog’s life. The clinical symptoms of HNPK in Greyhounds are exclusively restricted to the outermost skin of the nose.

    Initial lesions may be visible in puppies. However, clinical signs typically become more apparent as dogs age.

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  • Diagnosis

    Veterinarians will typically diagnose this condition with a direct examination of the dog's nose and likely a tissue biopsy.

  • Treatment

    Treatment options are mostly limited to the daily application of a topical moisturizer or other treatment to keep the nose moist.

  • What to do if your dog is at risk


    • Talk to your veterinarian about the best treatment option for your dog.
    • More severe cases may require medical intervention, and secondary infections may occur. Be careful when cleaning the dog's nose.

  • Genetic Information

    This variant was first identified in the Greyhound.

    HNPK is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the variant to show clinical signs from it.

    Gene names:

    SUV39H2 Intron 4 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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