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This is a Skeletal condition.


What is Hypophosphatasia?

Hypophosphatasia (HPP) is a metabolic bone disease characterized by defective skeletal mineralization and is caused by mutations in the alkaline phosphatase gene (ALPL).

What are the signs & symptoms that develop in affected dogs?

Affected dogs may exhibit a crouched stance, reluctance to move, generalized muscle weakness, deformed joints, and hyperextension of the wrist and ankle joints. Seizures may be observed.

When do signs and symptoms develop?

Puppies are affected from birth. This disease is typically diagnosed in young puppies from birth to a few months of age.

How do vets diagnose this condition?

Hypophosphatasia is diagnosed through clinical history, genetic testing, X-rays showing decreased mineralization of the bone, and certain blood chemistry abnormalities.

How is this condition treated?

Hypophosphatasia cannot be treated. Keeping your affected dog comfortable and giving them the best quality of life you can are the only actions you can take at home.

What actions should I take if my dog is affected?

  • Owners should consult with their veterinarian about their dog's quality of life. Due to the severity of the disease, most dogs are euthanized between a few weeks to a few months of age.
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