Leonberger Polyneuropathy 1

Brain and Spinal Cord

Leonberger Polyneuropathy (LPN) 1 is a progressive condition that primarily affects the nerves that communicate with the hind limbs and the larynx, or voicebox.

  • Signs and symptoms

    Affected dogs often tire easily (exercise intolerance) and display gait abnormalities, especially in the hind limbs. Due to LPN's effects on the larynx, affected dogs may often be very noisy breathers or may even have difficulty breathing.

    Signs can develop as early as one year of age.

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  • Diagnosis

    Unless a genetic basis is suspected due to the age, breed, or history of the dog, diagnostics must be performed to rule out infectious, inflammatory, or neoplastic causes.

  • Treatment

    There is no treatment for this disorder. Certain medications may be prescribed to control symptoms.

  • What to do if your dog is at risk


    • Keeping your affected dog comfortable and giving them the best quality of life you can are the only actions you can take at home.

  • Genetic Information

    This mutation was first described in the Leonberger and Saint Bernard.

    This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs. However, this mutation is incompletely penetrant, meaning that not all dogs with two copies of the mutation will show clinical signs.

    Gene names:

    ARHGEF10 Exon 17 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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