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Neurologic

This is a Brain and Spinal Cord condition.

Leonberger Polyneuropathy 1

What is LPN1?

Also observed in the St. Bernard, Leonberger Polyneuropathy (LPN) 1 is a progressive condition that primarily affects the nerves that communicate with the hind limbs and the larynx, or voicebox. Affected dogs often tire easily (exercise intolerance) and display gait abnormalities, especially in the hind limbs; because of LPN's effects on the larynx, affected dogs may often be very noisy breathers or may even have difficulty breathing. LPN1 has been mapped to a mutation in the AHRGEF10 gene; an additional mutation, termed LPN2, is also associated with LPN but maps to the GJA9 gene.

What are the signs & symptoms that develop in affected dogs?

Affected dogs often tire easily (exercise intolerance) and display gait abnormalities, especially in the hind limbs. Due to LPN's effects on the larynx, affected dogs may often be very noisy breathers or may even have difficulty breathing.

When do signs and symptoms develop?

Signs can develop as early as one year of age.

How do vets diagnose this condition?

Unless a genetic basis is suspected due to the age, breed, or history of the dog, diagnostics must be performed to rule out infectious, inflammatory, or neoplastic causes.

How is this condition treated?

There is no treatment for this disorder. Certain medications may be prescribed to control symptoms.

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