Lethal Acrodermatitis, LAD

skin & connective tissue

Lethal Acrodermatitis is a severe condition characterized by ulcerated skin lesions on the paws and head and a coat color dilution. The immunodeficiency common with this condition also causes intestinal upset, bronchopneumonia, and a general failure to thrive.

  • Signs and symptoms

    Signs include red and ulcerated patches on the head and paws and coat color dilution. The skin lesions progress to the legs and muzzle. Respiratory signs, diarrhea, and poor growth are also common.

    Signs are often first recognized in puppies as young as 3-4 weeks of age.

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  • Diagnosis

    Genetic testing and clinical signs can be used to diagnose this condition.

  • Treatment

    Unfortunately, there is no treatment for this condition. Certain medications can help control the infections for a period of time, but most puppies are euthanized early in life.

  • What to do if your dog is at risk


    • Follow your veterinarian's recommendations and give any medications as prescribed.

  • Genetic Information

    This mutation was first described in the Bull Terrier and Miniature Bull Terrier.

    This mutation has an autosomal recessive inheritance, meaning that dogs must have two copies of the mutation in order to show clinical signs.

    Gene names:

    MKLN1 ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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