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Skeletal

This is a Skeletal condition.

Osteogenesis Imperfecta

What is OI?

Our bones are equal parts rigid and flexible, making them capable of withstanding high impact as well as constant tension from attached muscle tendons and ligaments. Dogs affected with OI have lost the flexible part of the bone, which is primarily made of Type I collagen. This leads to extremely brittle bones and teeth. Type I collagen is also important in joints; as such, affected dogs can also present with hyperflexible joints and joint pain.

What are the signs & symptoms that develop in affected dogs?

Affected dogs often present to the vet for spontaneous bone fractures, tooth fractures and loss, and joint pain.

When do signs and symptoms develop?

Signs are first recognized in puppies.

How do vets diagnose this condition?

Genetic testing, clinical signs, radiographs, and laboratory tests are all used to diagnose this condition.

How is this condition treated?

Currently, there is no treatment for this condition. Medications may be prescribed to help with pain.