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This is a Skeletal condition.

Osteogenesis Imperfecta

What is OI?

A disease of bone strength and flexibilty, affected dogs often present to the vet for spontaneous bone fractures, tooth fractures and loss, and joint pain; these symptoms can be managed supportively but require close monitoring. Our bones are equal parts rigid and flexible, making them capable of withstanding high impact as well as constant tension from attached muscle tendons and ligaments. Dogs affected with OI have lost the flexible part of the bone, which is primarily made of Type I collagen. This leads to extremely brittle bones and teeth. Type I collagen is also important in joints; as such, affected dogs can also present with hyperflexible joints and joint pain. OI has been described in a variety of breeds including the Beagle, Collie, Golden Retriever, Dachshund, Poodle, Norwegian Elkhound, and the Bedlington Terrier, but the genetic bases have only been defined in a few of these breeds. All mutations known to cause OI in dogs lie within the genes that code for Type I collagen itself (which has multiple parts or subunits) or in genes that are required for collagen synthesis.

What are the signs & symptoms that develop in affected dogs?

Affected dogs often present to the vet for spontaneous bone fractures, tooth fractures and loss, and joint pain.

When do signs and symptoms develop?

Signs are first recognized in puppies.

How do vets diagnose this condition?

Gentic testing, clinical signs, radiographs, and laboratory tests are all used to diagnose this condition.

How is this condition treated?

Currently, there is no treatment for this condition. Medications may be prescribed to help with pain.

What actions should I take if my dog is affected?

Give your dog medications as prescribed to help with pain and inflammation. Try to minimize risk for injuries due to the chance for a bone fracture to occur.

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