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This is a hormone condition.

Proportionate Dwarfism

What is Proportionate Dwarfism?

Embark’s data suggests that this variant in the GH1 gene may contribute to a smaller body size. The original publication predicts this is due to a growth hormone (GH) deficiency. However, adult body size is influenced by several different genetic variants. Other changes noted by the publication, including retained baby teeth, persistent puppy-like coats, and low blood sugar have been occasionally reported by owners of dogs with two copies of this variant. These changes may or may not be associated with this variant.

What are the signs & symptoms that develop in affected dogs?

A smaller-than-expected adult weight is possible. Rarely, dogs with this variant may have low blood sugar, retained baby teeth, and a persistent puppy-like coat. Low blood sugar, if it occurs, causes lethargy and weakness. However, these issues are present across multiple toy breeds and may not be caused by this variant.

When do signs and symptoms develop?

Dogs with this variant may never show clinical signs. Smaller stature may be noticeable if the puppy grows at a different rate than littermates without this variant. Low blood sugar is a potential issue common to most toy breeds but could persist beyond four months of age. Retained puppy teeth and puppy-like coats can only be noted at more than six months of age.

How do vets diagnose this condition?

Clinical history, genetic testing, and laboratory testing can be used to diagnose this form of Proportionate Dwarfism. Further research is needed to determine the full effects of this variant.

How is this condition treated?

Our internal data suggests that most dogs with two copies of this variant will not require additional care than other toy breed puppies. If a complication occurs, your veterinarian may recommend various treatments, including correcting blood sugar or extracting retained baby teeth.

What actions should I take if my dog is affected?

  • Monitor for signs of hypoglycemia, including not eating, lethargy, and inability to stand. Call your veterinarian immediately for advice if you notice these signs.
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