Raine Syndrome


While Raine Syndrome causes a number of craniofacial abnormalities in human patients, in dogs, the most predominant sign of the condition is significant tooth wear, which leads to irritation of the dental pulp and considerable tooth pain.

  • Signs and symptoms

    Worn teeth that may have cracks, display discolored enamel, or exposed pulp can be seen in affected dogs.

    Signs are often first recognized in adults.

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  • Diagnosis

    Genetic testing and clinical signs can be used to diagnose this condition.

  • Treatment

    Routine dental treatments including tooth extraction is used to manage this disease.

  • What to do if your dog is at risk


    • Please follow your veterinarian's advice on dental care, which may include brushing teeth regularly and routine anesthetic cleanings.

  • Genetic Information

    This mutation was first described in the Border Collie.

    This mutation has an autosomal recessive inheritance, meaning that dogs must have two copies of the mutation in order to show clinical signs.

    Gene names:

    FAM20C ‐ chr

    Inheritance type:


  • Breeds affected

    This health condition affects the following breeds

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