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This is a Metabolic condition.

Mucopolysaccharidosis Type VI, Maroteaux-Lamy Syndrome, MPS VI

What is MPS VI?

A lysosome is a structure within the cell that digests and removes waste. When the lysosome cannot recycle waste properly, the waste accumulates and causes the cell to die. Mucopolysaccharidosis VI (MPS VI) is a lysosome disorder in which a specific glycosaminoglycan (GAG) accumulates in lysosomes. This causes progressive health issues including stunted growth, skeletal deformities, and eye problems.

What are the signs & symptoms that develop in affected dogs?

Affected dogs may display facial, limb, and stature abnormalities. They may experience progressive gait changes and decreased mobility, along with or in addition to joint hyperlaxity (extreme flexibility). They may also develop cloudy eyes.

When do signs and symptoms develop?

You may notice the first signs of dwarfism as early as three months of age, and eye abnormalities by seven months of age.

How do vets diagnose this condition?

Your dog's veterinarian may use genetic testing, clinical signs, and history to diagnose this disease. Urinalysis, bloodwork, and radiographs can all be useful tools for making a diagnosis.

How is this condition treated?

Currently, care is mostly supportive in nature.

What actions should I take if my dog is affected?

  • Many dogs have been able to live for several years with MPS VI, but frank discussions about quality of life are warranted.
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