Congenital Myasthenic Syndrome, CMS
This is a non-progressive disease characterized by episodes of exercise intolerance and weakness
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Signs and symptoms
Affected puppies can usually play or run for up to a half hour, after which their strides get progressively shorter and the dog collapses. After resting, dogs show no ill effects.
Signs first appear in puppies, typically between 3-4 months of age. -
Diagnosis
Genetic testing, blood work, neurological tests, and clinical signs can be used to diagnose this condition.
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Treatment
CMS is a lifelong condition that thankfully does not progress; affected dogs typically enjoy a good quality of life besides their exercise intolerance.
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What to do if your dog is at risk
Actions
- Minimizing intense exercise may help reduce clinical signs. Please follow the recommendations from your veterinarian.
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Genetic Information
This mutation was first described in Old Danish Pointing Dogs.
This disease is inherited in an autosomal recessive manner, meaning that affected dogs must have two copies of the mutation to show clinical signs.
Gene names:
CHAT (Exon 6) ‐ chr
Inheritance type:
recessive
Citations:
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Breeds affected
This health condition affects the following breeds
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